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December 21, 2017

KFRE Validated for pediatric kidney patients

December 20, 2017

A study published in JAMA Pediatrics has validated the use of the Kidney Failure Risk Equation, invented by Dr. Navdeep Tangri at Seven Oaks Chronic Disease Innovation Centre, for children with kidney disease.

The study by Dr. Erica Winnicki and colleagues from the University of California in San Francisco looked at retrospective data for 603 children with chronic kidney disease and found that applying the Kidney Failure Risk Equation (KFRE) was associated with predicting kidney failure at 1, 2 and 5 years. This means that going forward, applying the KFRE for children can determine risk for kidney failure and guide the timing and decision-making for dialysis and kidney transplants.

The study results were accompanied by an editorial in the same edition of JAMA Pediatrics making the case for changing clinical practice to use the KFRE with pediatric kidney patients, but with further evaluation to improve pediatric risk prediction over the long term.

The editorial Time to Implement the Kidney Failure Risk Equation into Pediatric Practice was authored by University of Manitoba Pediatric Nephrologist Dr. Allison Dart together with the Chronic Disease Innovation Centre investigator Dr. Tangri who invented the KFRE and Dr. Paul Komenda who has worked on numerous studies and implementation of the KFRE.

In the editorial Dart et al support the use of KFRE with pediatric kidney patients but point out that “although the ability of KFRE to estimate short and intermediate-term outcomes is robust, the ability of the KFRE to estimate longer-term outcomes is less reliable.” The editorial suggests that with younger patient populations the long term risk of kidney failure is high and more accurate longer term prediction would be valuable to clinicians and the patients.

The study and editorial were also both highlighted in an article in Medpage and the latest issue of Renal and Urology News.

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