Publications

Seven Oaks Hospital has developed a rich culture of curiosity, ideation, and the collective determination to discover and deploy better ways of doing things. Today, world-leading researchers are drawn to the Seven Oaks Hospital community of innovation, and the momentum continues to build.

Publication

Clinical epidemiology of cardiac disease in renal transplant recipients

Dr. Claudio Rigatto

Seminars in dialysis

Publication Category

Abstract: Cardiovascular disease (CVD) is the major cause of death among renal transplant recipients (RTRs), accounting for 17-50% of deaths. Echocardiographic disorders and clinical CHF occur far more frequently in RTRs than in the general population, suggesting that renal transplantation may be a state of accelerated heart failure. In contrast, the incidence of ischemic heart disease (IHD) in renal transplant recipients (RTRs) is similar to that in the Framingham cohort. Age, diabetes, and gender remain important markers of risk for both disorders. Smoking, hyperlipidemia, and hypertension appear to be the major reversible risk factors for IHD, while anemia and hypertension are major reversible risk factors for cardiomyopathy. Clinical trials are needed to define optimum targets for treatment of these risk factors, especially hypertension and anemia.

Publication

The intersection of risk and benefit: is warfarin anticoagulation suitable for atrial fibrillation in patients on hemodialysis

Dr. Claudio Rigatto

Sood MM, Komenda P, Sood AR, Rigatto C, Bueti J.

Chest

Publication Category

Abstract: In patients with ESRD who are undergoing hemodialysis, the rates for both stroke and bleeding are 3 to 10 times higher than that for the general population. Furthermore, the proportion of hemorrhagic to ischemic strokes has increased, making the decision of whether to initiate anticoagulation problematic. In this commentary, we discuss the existing literature for stroke in atrial fibrillation, stroke type, risk reduction with anticoagulation, and bleeding risks in the hemodialysis population. We comment on validated risk stratification models of stroke prevention and bleeding and their applicability to patients undergoing hemodialysis. Finally, we recommend treatment strategies that are based on the existing state of knowledge.

Publication

Serum creatinine measurement immediately after cardiac surgery and prediction of acute kidney injury

Dr. Claudio Rigatto

Ho J, Reslerova M, Gali B, Nickerson PW, Rush DN, Sood MM, Bueti J, Komenda P, Pascoe E, Arora RC, Rigatto C.

American Journal of Kidney Diseases

Publication Category

Background: After heart surgery, acute kidney injury (AKI) confers substantial long-term risk of death and chronic kidney disease. We hypothesized that small changes in serum creatinine (SCr) levels measured within a few hours of exit from the operating room could help discriminate those at low versus high risk of AKI.

Research Division · Seven Oaks Chronic Disease Innovation Centre
2300 McPhillips Street · Winnipeg, Manitoba · R2V 3M3 · 204‑631‑3834