Publication Category

Intradialytic exercise preconditioning: an exploratory study on the effect on myocardial stunning

Penny, J, Salerno, F, Brar, R, Garcia, E, Rossum, K, McIntytre, C, Bohm, C.

Nephrology Dialysis Transplantation

Study Description

Exercise preconditioning provides immediate protection against cardiac ischemia in clinical/preclinical studies in subjects without chronic kidney disease. In individuals requiring renal replacement therapy, hemodialysis (HD) results in significant circulatory stress, causing acute ischemia with resultant recurrent and cumulative cardiac injury (myocardial stunning). Intradialytic exercise (IDE) has been utilized to improve functional status in individuals receiving HD. The objective of this study was to explore the role of IDE as a preconditioning intervention and assess its effect on HD-induced myocardial stunning.

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