Clinical epidemiology of cardiac disease in renal transplant recipients
Dr. Claudio Rigatto
Seminars in dialysis
Abstract: Cardiovascular disease (CVD) is the major cause of death among renal transplant recipients (RTRs), accounting for 17-50% of deaths. Echocardiographic disorders and clinical CHF occur far more frequently in RTRs than in the general population, suggesting that renal transplantation may be a state of accelerated heart failure. In contrast, the incidence of ischemic heart disease (IHD) in renal transplant recipients (RTRs) is similar to that in the Framingham cohort. Age, diabetes, and gender remain important markers of risk for both disorders. Smoking, hyperlipidemia, and hypertension appear to be the major reversible risk factors for IHD, while anemia and hypertension are major reversible risk factors for cardiomyopathy. Clinical trials are needed to define optimum targets for treatment of these risk factors, especially hypertension and anemia.